P114 Increased serum levels of the migraine biomarker calcitonin gene related peptide alpha in a newly diagnosed inflammatory bowel disease population: a new mediator for the gut-brain-axis

Abstract Background Calcitonin gene related peptide (CGRP) is known to be the most potent vasodilator of body, and it promotes migration inflammatory cells. CGRPβ isoform located along enteric nervous system, CGRPα mainly present in central system. key molecule migraine, an entity with digestive symptoms. It has been suggested that migraine prevalence increased bowel disease (IBD). The aim study was assess serum levels patients newly diagnosed IBD, stratified by diagnosis, unravel its potential role disease. Methods concentrations were measured ELISA (CUSABIO, China) early morning samples IBD. Classification (ulcerative colitis- UC, Crohn’s disease- CD or unclassified U-IBD), demographic data treatment during sample collection also collected. To establish a interviewed about prior diagnosis validated ID-migraine questionnaire used diagnose migraine. results compared healthy controls (HC) matched age sex. Statistical analysis performed using SPSS Mann-Whitney Dunn's tests. Results Sixty-two IBD (mean 47.9±16.3 years, 62.5% females) 71 HC 48.2±16.7 64.8% females). Samples collected between 0 249 days after stablished (median 50.5 days, interquartile range 26.75-64.5 days). We included 27 CD, 31 UC 4 U-IBD. Baseline characteristics are shown table 1. Fifteen female met criteria (22.7%). Serum significantly (59.7±26.3 pg/mL), (43.6±25.3 pg/mL, p<0.0001). remained elevated as both (74.8±27.3 p< 0.001) without (58.6±24.4 p<0.05), though those (p<0.05). These figures 1 2. Conclusion regardless which could indicate this pathophysiology results, especially higher suggest bidirectional, shared further example clinical relevance gut-brain axis. Supported Instituto de Salud Carlos III (PI20/01358).